š Tenecteplase Injection 40 mg/vial
š¹ 1. Prescription / Indication:
Tenecteplase 40 mg is prescribed as a thrombolytic agent in emergency cardiac care, especially for:
- Acute ST-Elevation Myocardial Infarction (STEMI)
- Given within 12 hours of symptom onset
- As a single IV bolus injection
- Commonly used when PCI (angioplasty) is not available promptly
- May also be used off-label for:
- Massive pulmonary embolism (PE)
- Acute ischemic stroke (in controlled settings)
š¹ 2. Description:
- Form: Lyophilized powder for injection
- Strength: 40 mg per vial
- Route: Intravenous bolus
- Reconstitution: With sterile water for injection (typically 10 mL)
- Appearance: White to pale yellow powder; forms a clear solution after reconstitution
š¹ 3. Advantages:
- Single bolus injection ā fast, no infusion required
- Longer half-life than alteplase (tPA)
- Higher fibrin selectivity ā less risk of systemic bleeding
- Rapid coronary artery reperfusion
- Less nursing time and equipment vs traditional thrombolytics
š¹ 4. Nature / Pharmacological Class:
- Class: Thrombolytic (fibrinolytic)
- Type: Recombinant tissue plasminogen activator (rtPA) ā modified
- Mechanism:
- Converts plasminogen to plasmin, which breaks down fibrin clots
- Selective for fibrin-bound plasminogen ā acts more on clots than circulating proteins
š¹ 5. Common Packaging:
- Single-dose vial containing 40 mg (8000 IU) powder
- Comes with:
- Sterile water for injection for reconstitution
- Transfer device or filter needle (depending on manufacturer)
- Packed in sterile box with full instructions
š¹ 6. Storage:
- Unopened vials:
- Store at 2Ā°Cā8Ā°C (refrigerated)
- Do not freeze
- Protect from light
- After reconstitution:
- Use immediately
- If needed, may be stored at 2ā8Ā°C for up to 8 hours
- Discard any unused portion
š¹ 7. Patient Advice / Counseling:
- Tenecteplase is given in hospital under cardiac monitoring
- Inform doctors of:
- Any recent surgery, trauma, stroke, or bleeding
- History of hypertension, ulcers, or allergy to thrombolytics
- Common side effects:
- Mild bleeding from gums, nose, injection site
- Rare but serious: internal bleeding, stroke, allergic reaction
- Avoid invasive procedures after injection (e.g., catheterization, IM injections)
- Remain under observation for at least 24 hours
š¹ 8. Purpose / Clinical Use:
- Dissolves blood clots in coronary arteries
- Reduces myocardial damage and death risk in acute heart attacks
- Used when primary PCI is delayed or unavailable
- An effective part of pharmacoinvasive strategy in STEMI care