💉 Tenecteplase Injection 30 mg/vial
🔹 1. Prescription / Indication:
Tenecteplase 30 mg is a thrombolytic (clot-dissolving) agent prescribed primarily for:
- Acute ST-elevation Myocardial Infarction (STEMI)
- Within 12 hours of symptom onset
- Reduces mortality and improves coronary reperfusion
- May also be used (off-label/experimental) for:
- Massive Pulmonary Embolism
- Ischemic Stroke (under controlled conditions)
🔴 Strictly used in hospital/emergency settings, usually in cardiac care units (CCU)
🔹 2. Description:
- Form: Lyophilized powder for injection
- Strength: 30 mg per vial (equivalent to 6,000 IU)
- Route: IV bolus injection (given over ~5 seconds)
- Reconstitution: With sterile water for injection (usually 10 mL)
- Appearance: White to pale yellow powder; forms clear solution when reconstituted
🔹 3. Advantages:
- Single IV bolus dosing — fast & convenient
- Higher fibrin specificity → less systemic bleeding risk
- Longer plasma half-life than alteplase → no infusion needed
- Rapid reperfusion of occluded coronary arteries
- Greater patient comfort vs longer infusions
🔹 4. Nature / Pharmacological Class:
- Class: Fibrinolytic / Thrombolytic agent
- Type: Genetically engineered variant of tPA (tissue plasminogen activator)
- Mechanism of Action:
- Converts plasminogen → plasmin
- Plasmin degrades fibrin in thrombi (clots), restoring blood flow
🔹 5. Common Packaging:
- Vial containing 30 mg lyophilized powder (single-dose)
- Comes with:
- Pre-filled syringe or ampoule of sterile water for injection
- Transfer needle or adapter for safe reconstitution
- Typically packed in a sterile box for IV bolus administration
🔹 6. Storage:
- Unopened vial:
- Store at 2°C to 8°C (refrigerated)
- Protect from light
- Reconstituted solution:
- Use immediately or within 8 hours if kept at 2–8°C
- Do not freeze
- Discard any unused portion
🔹 7. Patient Advice / Counseling Points:
Administered only by trained professionals in hospitals. Key points include:
- Inform doctor if:
- Patient has recent surgery, trauma, or bleeding
- History of stroke, hypertension, or bleeding disorders
- May cause:
- Mild bleeding (gums, injection site, urine)
- Severe bleeding (rare) — monitored closely
- Allergic reactions (rare)
- Avoid invasive procedures for 24 hours after injection
- Patient is typically monitored in ICU or CCU for ECG, BP, bleeding
🔹 8. Purpose / Clinical Use:
- Emergency thrombolysis in acute myocardial infarction
- Dissolves coronary thrombus, restoring perfusion
- Reduces mortality, infarct size, and long-term heart failure
- An important alternative to primary PCI (angioplasty) where not immediately available