Here is the detailed information for Tenecteplase Injection 30 mg/vial:
💉 Tenecteplase – Injection 30 mg/vial
🔹 Description:
Tenecteplase is a genetically engineered variant of tissue plasminogen activator (tPA) used as a thrombolytic agent to dissolve blood clots.
🔬 Nature / Drug Class:
- Nature: Thrombolytic (clot buster)
- Drug Class: Fibrinolytic agent / Recombinant tissue plasminogen activator (rt-PA)
🎯 Purpose / Indications:
- Acute myocardial infarction (STEMI) – to dissolve clots in coronary arteries
- Used within 6 hours of symptom onset to restore perfusion
- Reduces mortality and complications post-heart attack
✅ Advantages:
- Single bolus injection – faster and easier administration compared to alteplase
- Higher fibrin specificity – reduces risk of systemic bleeding
- Longer half-life – allows one-time dosing
- Rapid action – initiates clot lysis quickly
📦 Common Packaging:
- Lyophilized powder for injection
- Supplied in 30 mg vials with sterile water for reconstitution
- Often includes disposable syringe or transfer needle
- Cold chain required – stored in refrigerator (2–8°C)
⚠️ Patient Advice / Precautions:
- Only for hospital use under supervision of a cardiologist or critical care physician
- Monitor for signs of bleeding, stroke, or hypotension
- Contraindicated in:
- Active internal bleeding
- History of hemorrhagic stroke
- Recent surgery or trauma
- Renal and hepatic function should be assessed before use
- Do not shake vigorously during reconstitution