Here is the detailed information for Tenecteplase Injection 30 mg/vial:
💉 Tenecteplase – Injection 30 mg/vial
🔹 Description:
Tenecteplase is a genetically engineered variant of tissue plasminogen activator (tPA). It promotes the breakdown of blood clots by converting plasminogen to plasmin, the major enzyme responsible for clot dissolution.
🔬 Nature / Drug Class:
- Nature: Recombinant protein
- Drug Class: Fibrinolytic / Thrombolytic agent (tPA analog)
🎯 Purpose / Indications:
- Acute ST-elevation myocardial infarction (STEMI)
- Used to dissolve blood clots in emergency settings
- Helps restore blood flow to the heart, reducing damage during heart attacks
✅ Advantages:
- Single bolus injection – fast and easy administration
- Greater fibrin specificity and resistance to PAI-1 (plasminogen activator inhibitor) than alteplase
- Faster reperfusion and reduced treatment time in acute MI
- Reduced systemic bleeding risk compared to some older agents
📦 Common Packaging:
- 30 mg single-use vial (lyophilized powder)
- Supplied with sterile water for reconstitution
- Administered via intravenous bolus injection
⚠️ Patient Advice / Precautions:
- To be administered in hospital or ICU settings only
- Contraindicated in recent stroke, active bleeding, severe hypertension, or trauma
- Monitor for bleeding complications, especially intracranial hemorrhage
- ECG and vitals must be continuously monitored during and after administration
- Use with caution in patients on anticoagulants or antiplatelet therapy