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💉 Irinotecan Hydrochloride Trihydrate Injection 100 mg/vial
📘 Description:
Irinotecan is a cytotoxic chemotherapy drug used to treat certain types of cancer. It interferes with DNA replication in cancer cells, thereby slowing or stopping tumor growth. Supplied as a sterile vial for intravenous use.
🌿 Nature / Drug Class:
- Nature: Semi-synthetic derivative of camptothecin
- Drug Class: Topoisomerase I Inhibitor, Antineoplastic (anticancer) agent
🎯 Purpose / Indications:
- Treatment of metastatic colorectal cancer (first-line or second-line therapy)
- Also used in cancers of the lung, cervix, stomach, and others (off-label or in clinical protocols)
- Often combined with fluorouracil (5-FU) and leucovorin (FOLFIRI regimen)
✅ Advantages:
- Effective in advanced and metastatic cancer stages
- Can be used both as monotherapy or in combination regimens
- Helps improve progression-free survival and overall survival
- Active in irinotecan-sensitive tumors, especially colorectal
📦 Common Packaging:
- Single-use glass vial containing 100 mg/5 mL or 100 mg/2 mL of Irinotecan Hydrochloride
- Packaged in boxes with 1 vial per carton
- Preservative-free formulation
⚠️ Patient Advice / Precautions:
- Should only be administered by trained healthcare professionals in a hospital/clinic
- Common side effects: Diarrhea (early and late), neutropenia, nausea, vomiting
- Severe diarrhea may require prompt management with loperamide or hydration
- Monitor blood counts, liver function, and hydration status regularly
- Pregnancy Category D – avoid during pregnancy or breastfeeding
- Inform doctor about any liver disease, infections, or genetic enzyme conditions (UGT1A1 deficiency)