Here is the complete information for:
💉 Bendamustine Hydrochloride Injection 100 mg/vial
🧪 Composition:
- Each vial contains:
Bendamustine Hydrochloride 100 mg
(as lyophilized powder, equivalent to 100 mg base)
🌐 Therapeutic Class:
- Antineoplastic Agent – Alkylating Agent
- Used in hematologic cancers
✅ Indications:
- Chronic Lymphocytic Leukemia (CLL)
- Indolent Non-Hodgkin’s Lymphoma (NHL) (that progressed during or within 6 months of rituximab therapy)
- Multiple Myeloma (off-label in some settings)
⚖️ Dosage & Administration:
| Indication | Dose | Cycle |
|---|---|---|
| CLL | 100 mg/m² IV | Day 1 and 2 of a 28-day cycle (x6) |
| NHL | 120 mg/m² IV | Day 1 and 2 of a 21-day cycle (x6–8) |
- Infusion time: 30–60 minutes
- Must be reconstituted and diluted before IV use
💧 Reconstitution & Dilution:
- Reconstitute 100 mg vial with 4 mL of Sterile Water for Injection (25 mg/mL)
- Dilute required dose in 0.9% Sodium Chloride to final volume of 500 mL
- Use non-PVC infusion sets
- Do not mix with dextrose or other drugs
⚠️ Precautions:
- Severe myelosuppression
- Monitor for infections
- Risk of tumor lysis syndrome
- Hepatic/renal impairment: Adjust dose carefully
- Infusion-related reactions: premedication with antihistamines or corticosteroids may be needed
🚫 Contraindications:
- Known hypersensitivity
- Severe liver dysfunction
- Pregnancy & lactation
- Uncontrolled active infection
💥 Common Side Effects:
- Neutropenia, anemia, thrombocytopenia
- Nausea, vomiting, diarrhea
- Fatigue, fever
- Rash, infusion reactions
- Elevated liver enzymes
👩⚕️ Special Populations:
- Pregnancy Category D – avoid
- Lactating women – contraindicated
- Use caution in elderly and those with comorbidities
📦 Storage:
- Store unopened vials at 2–8°C (Refrigerated)
- Protect from light
- After reconstitution:
- Room Temp: Use within 3 hours
- Refrigerated: Use within 24 hours