Here is the detailed information for:
💉 Bendamustine Hydrochloride Injection 25 mg
🧪 Composition:
- Each vial contains:
Bendamustine Hydrochloride 25 mg
(as a lyophilized powder for reconstitution)
🌐 Therapeutic Class:
- Alkylating Agent (Chemotherapy)
- Used in treatment of hematologic malignancies
✅ Indications / Uses:
- Chronic Lymphocytic Leukemia (CLL)
- Non-Hodgkin’s Lymphoma (NHL) – indolent types
- Multiple Myeloma (off-label in some regions)
⚖️ Dosage & Administration:
- Dose and schedule vary depending on indication.
Example for CLL:- 100 mg/m² IV on Days 1 & 2 of a 28-day cycle, for up to 6 cycles
- For NHL:
- 120 mg/m² IV on Days 1 & 2 of a 21-day cycle
- Reconstitution:
- Reconstitute with Sterile Water for Injection
- Further dilute in 0.9% Sodium Chloride Injection
- Administer via IV infusion over 10–60 minutes
⚠️ Precautions:
- Myelosuppression (neutropenia, thrombocytopenia)
- Infections – increased risk
- Infusion reactions – fever, chills, rash, hypotension
- Tumor lysis syndrome
- Monitor CBC, renal, hepatic function
🚫 Contraindications:
- Hypersensitivity to Bendamustine
- Severe hepatic impairment
- Breastfeeding
💥 Common Side Effects:
- Nausea, vomiting
- Fatigue
- Fever
- Rash
- Mucositis
- Anemia, neutropenia
- Increased liver enzymes
👩⚕️ Special Populations:
- Pregnancy: Contraindicated (Category D) – teratogenic
- Lactation: Not recommended
- Geriatrics: Use with caution – monitor for toxicity
📦 Storage:
- Store unopened vials at 2°C to 8°C (Refrigerated)
- Protect from light
- After reconstitution:
- Use within 3 hours (room temp) or 24 hours (refrigerated)