Here is the full information for:
💊 Daclatasvir Tablet 30 mg
🧪 Composition:
- Daclatasvir dihydrochloride, equivalent to Daclatasvir 30 mg
🌐 Therapeutic Class:
- Antiviral (Hepatitis C treatment)
- NS5A replication complex inhibitor
- Used as part of combination therapy for Chronic Hepatitis C Virus (HCV) infection
✅ Indications / Uses:
- Chronic HCV infection (genotypes 1, 3, and others)
- Always used in combination with:
- Sofosbuvir
- ± Ribavirin
- Effective in:
- Treatment-naïve and experienced patients
- Patients with and without cirrhosis
⚖️ Dosage Guidelines:
- Standard dose: 60 mg once daily
- 30 mg dose is used when Daclatasvir interacts with certain medicines:
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) → reduce dose to 30 mg
- When co-administered with atazanavir, ritonavir, or other boosters
- Duration of therapy: 12–24 weeks depending on:
- HCV genotype
- Liver status
- Previous treatment history
⚠️ Precautions:
- Always use in combination, not as monotherapy
- Dose modifications may be required when used with certain antivirals or antiretrovirals
- Caution in patients with:
- Advanced liver disease
- Co-infection with HIV
- Monitor liver enzymes and viral load
🚫 Contraindications:
- Hypersensitivity to Daclatasvir
- Co-administration with:
- Strong enzyme inducers (e.g., rifampin, carbamazepine, phenytoin, St. John’s Wort) — can lower Daclatasvir levels and reduce efficacy
💥 Common Side Effects (usually due to combination therapy):
- Fatigue
- Headache
- Nausea
- Anemia (especially with ribavirin)
- Insomnia
👩⚕️ Use in Special Populations:
- Pregnancy: Use caution (especially with Ribavirin combinations)
- Lactation: Avoid (no data available)
- Renal/Hepatic Impairment: No dose adjustment in mild to moderate cases
📦 Storage:
- Store at or below 30°C
- Keep away from direct light and moisture