Here is the detailed information for:
💊 Darunavir (600 mg) + Ritonavir (100 mg) Tablets
🧪 Composition:
- Darunavir – 600 mg
- Ritonavir – 100 mg
(Both as individual tablets or a fixed-dose combination)
🌐 Therapeutic Class:
- Antiretroviral (ARV)
- Darunavir: Protease Inhibitor (PI)
- Ritonavir: Pharmacokinetic enhancer (boosts Darunavir levels)
✅ Indications / Uses:
- Treatment of HIV-1 infection in:
- Adults
- Adolescents (weighing ≥40 kg)
- Used in combination with other antiretroviral agents
⚖️ Dosage:
- Standard regimen for treatment-experienced patients:
- Darunavir 600 mg + Ritonavir 100 mg
- Twice daily (BID) with food
⚠️ Precautions:
- Always given with food – improves absorption
- Caution in patients with hepatic impairment
- Monitor for liver function, blood glucose, lipid profile
- Significant drug-drug interactions (CYP3A4 substrate/inhibitor)
- Can cause skin rash, sometimes severe
🚫 Contraindications:
- Known hypersensitivity to Darunavir or Ritonavir
- Co-administration with drugs highly dependent on CYP3A for clearance, such as:
- Alfuzosin, amiodarone, lovastatin, simvastatin, rifampicin, midazolam (oral)
💥 Common Side Effects:
- Nausea, diarrhea
- Headache
- Rash
- Elevated cholesterol or triglycerides
- Liver enzyme abnormalities
- Hyperglycemia
- Fat redistribution
👩⚕️ Use in Special Populations:
- Pregnancy: Generally safe with caution; consult guidelines
- Breastfeeding: Not recommended (due to risk of HIV transmission)
- Pediatrics: Used in children ≥3 years (dose based on weight)
📦 Storage:
- Store below 30°C
- Keep in original container to protect from moisture