Here is the complete medical information for Valganciclovir Tablet 450 mg:
💊 Valganciclovir Tablet 450 mg
🧪 Generic Name:
Valganciclovir Hydrochloride
📦 Form & Strength:
- Tablet: 450 mg (as valganciclovir hydrochloride, equivalent to ganciclovir 370 mg)
🦠 Uses / Indications:
Valganciclovir is an antiviral medicine primarily used to treat or prevent cytomegalovirus (CMV) infections:
- CMV Retinitis in patients with AIDS
- Prevention of CMV disease in organ transplant recipients (especially kidney, heart)
⚖️ Dosage & Administration:
Take with food for best absorption
- Treatment of CMV Retinitis:
- Induction: 900 mg twice daily for 21 days
- Maintenance: 900 mg once daily
- CMV Prophylaxis in Transplant:
- 900 mg once daily, typically for 100–200 days (depending on organ type)
💡 Dose adjustments required in renal impairment (based on creatinine clearance)
⚠️ Precautions:
- Bone marrow suppression risk (neutropenia, anemia, thrombocytopenia)
- Regular CBC monitoring recommended
- Adjust dose in renal impairment
- Use contraception during and at least 90 days after treatment (teratogenic & carcinogenic risks)
🚫 Contraindications:
- Hypersensitivity to valganciclovir or ganciclovir
- Severe neutropenia or thrombocytopenia unless benefits outweigh risks
- Pregnancy (Category C – only if clearly needed)
💥 Common Side Effects:
- Hematologic: Neutropenia, anemia, thrombocytopenia
- Gastrointestinal: Diarrhea, nausea, vomiting, abdominal pain
- CNS: Headache, insomnia, confusion
- Others: Fever, rash, renal dysfunction (rare)
👶 Use in Children:
- Approved for CMV prophylaxis in pediatric transplant patients (≥4 months age)
- Dosing is weight and BSA-based
🧴 Storage:
- Store at room temperature (15–30°C)
- Keep away from moisture and light
- Handle with care (avoid crushing or breaking tablet; wash hands after handling)