Here is the full detail for Amikacin Injection 500 mg/mL:
💉 Amikacin Injection 500 mg/mL
🧪 Generic Name:
Amikacin Sulfate
💊 Form & Strength:
- Injection (for IV or IM use)
- Concentration: 500 mg/mL
- Commonly available in 1 mL vial or ampoule
→ Total content per ampoule: 500 mg
📦 Packaging & Storage:
- Amber or clear glass ampoule/vial (1 mL)
- Store at 15–25°C
- Do not freeze
- Protect from light
📌 Uses / Indications:
Used to treat serious Gram-negative bacterial infections, including:
- Septicemia
- Hospital-acquired pneumonia
- Urinary tract infections
- Abdominal infections
- Bone/joint infections
- Skin and soft tissue infections
- Post-surgical infections
💉 Administration:
- Intramuscular (IM): direct injection
- Intravenous (IV): dilute before infusion
(Typically diluted with NS or D5W and infused over 30–60 minutes)
🧮 Dosage Guidelines:
Doses vary based on infection severity, age, weight, and renal status.
- Adults:
15 mg/kg/day in divided doses every 12 hours
→ E.g., for a 70 kg adult = 1,050 mg/day (usually 500 mg twice a day) - Children:
15–20 mg/kg/day divided every 8–12 hrs - Neonates:
Initial: 10 mg/kg, then 7.5 mg/kg every 12–24 hours
⚠️ Precautions:
- Nephrotoxicity and ototoxicity risk → monitor renal function & hearing
- Adjust dose in renal impairment
- Avoid concurrent use with other nephrotoxic or ototoxic drugs
- Monitor serum drug levels during prolonged therapy
❌ Contraindications:
- Known allergy to aminoglycosides
- Use cautiously in myasthenia gravis or neuromuscular disorders
💥 Side Effects:
- Kidney damage (↑ creatinine, ↓ urine output)
- Hearing loss, tinnitus, balance issues
- Injection site pain
- Rare: fever, rash, dizziness, respiratory paralysis