Here is the detailed information for Amikacin Injection 100 mg/mL:
💉 Amikacin Injection 100 mg/mL
🧪 Generic Name:
Amikacin Sulfate
💊 Form & Strength:
- Injection (solution for IV/IM use)
- Concentration: 100 mg/mL
- Common pack sizes: 2 mL, 2.5 mL, or 4 mL ampoules/vials
📦 Packaging:
- Clear glass ampoules or vials
- Sterile solution
- Storage: Store below 25°C, protect from light
- Do not freeze
📌 Indications / Uses:
Used to treat serious bacterial infections, especially those caused by Gram-negative bacteria, including:
- Septicemia
- Respiratory tract infections
- Urinary tract infections
- Bone/joint infections
- Intra-abdominal infections
- Skin and soft tissue infections
- Hospital-acquired infections (e.g., ventilator-associated pneumonia)
💉 Route of Administration:
- Intramuscular (IM) or Intravenous (IV) infusion
- Dilution required for IV infusion
(usually diluted in 100–200 mL of 0.9% sodium chloride or 5% glucose and given over 30–60 minutes)
🧮 Dosage (General Guide):
Dosage depends on age, weight, kidney function, and severity of infection.
- Adults:
15 mg/kg/day in 1 or 2 divided doses
(Typical: 500 mg every 12 hours) - Children:
15–20 mg/kg/day in 2–3 divided doses - Neonates:
Initial: 10 mg/kg; then 7.5 mg/kg every 12–24 hours
⚠️ Precautions:
- Nephrotoxicity (monitor renal function)
- Ototoxicity (risk of hearing damage)
- Neuromuscular blockade in high doses
- Therapeutic Drug Monitoring (TDM) recommended for long-term use
❌ Contraindications:
- Known hypersensitivity to aminoglycosides
- Caution in patients with myasthenia gravis or Parkinson’s disease
💥 Common Side Effects:
- Nausea, vomiting
- Kidney damage (elevated creatinine)
- Hearing loss, tinnitus
- Injection site pain (IM)