Here is the detailed information for Procaine Benzylpenicillin Powder for Injection 1000 mg (=1 million IU):
💉 Procaine Benzylpenicillin Injection 1000 mg (= 1 million IU)
🧪 Generic Name:
Procaine Benzylpenicillin (also called Procaine Penicillin G)
💊 Form & Strength:
- Powder for Injection
- Strength: 1000 mg (equivalent to 1 million International Units – IU)
📦 Packaging:
- Packed in single-use vials as dry powder for intramuscular (IM) reconstitution
- Diluent: Sterile Water for Injection (or as specified)
- Storage: Store below 25°C; protect from light and moisture
- Do not freeze after reconstitution
📌 Indications / Uses:
- Moderate to severe infections caused by penicillin-sensitive organisms, including:
- Syphilis (early stages)
- Streptococcal infections (e.g., tonsillitis, scarlet fever)
- Rheumatic fever prophylaxis
- Pneumonia
- Erysipelas
- Skin/soft tissue infections
- Anthrax
💉 Administration & Dosage (General guidance):
- Route: Intramuscular injection only
- Adults: 600,000 IU to 1.2 million IU once daily
- Children: Dose adjusted based on age/weight (e.g., 25,000–50,000 IU/kg/day IM)
- Given once daily, as it provides a slow release of penicillin G into the bloodstream
⏳ Not suitable for IV use
⚠️ Precautions:
- Allergy: Contraindicated in penicillin hypersensitivity
- Caution in renal impairment
- Monitor for Jarisch–Herxheimer reaction in syphilis treatment
- May cause pain at injection site
❌ Contraindications:
- Known hypersensitivity to penicillin or procaine
- Do not administer intravenously or intrathecally
💥 Possible Side Effects:
- Local injection site reaction (pain, redness, swelling)
- Hypersensitivity (rash, fever, anaphylaxis)
- Dizziness, headache (due to procaine component)
- Rare: Seizures (especially with high doses)