Here is the detailed information for Meropenem Powder for Injection 1000 mg (1 g) (as trihydrate):
๐ Meropenem Powder for Injection 1000 mg (1 g)
๐งช Generic Name:
Meropenem (as trihydrate)
๐ Form & Strength:
- Form: Sterile lyophilized powder for injection
- Strength: 1000 mg (1 g) per vial
- Route: Intravenous (IV) or Intramuscular (IM)
๐ฆ Packaging:
- Glass vial with rubber stopper and sealed flip-off cap
- Typically packed as single-use vials, sometimes in boxes of 1 or 10 vials
- Reconstitution:
- With Sterile Water for Injection or 0.9% Sodium Chloride
- Storage:
- Store below 25ยฐC
- Protect from light and moisture
- Reconstituted solution should be used within 6 hours (room temp) or 24 hours (refrigerated)
๐ฌ Pharmacological Class:
- Carbapenem antibiotic
- Broad-spectrum ฮฒ-lactam effective against:
- Gram-positive, Gram-negative, anaerobic bacteria
๐ Indications / Uses:
- Complicated intra-abdominal infections
- Community-acquired and hospital-acquired pneumonia
- Skin and soft tissue infections
- Meningitis (bacterial)
- Urinary tract infections
- Febrile neutropenia (empiric therapy)
- Sepsis or bacteremia
๐ Dosage & Administration:
| Patient Group | Dosage | Frequency |
|---|---|---|
| Adults | 1 g IV | Every 8 hours or 12 hours (based on infection severity) |
| Children (>3 months) | 20โ40 mg/kg | Every 8 hours |
| Meningitis (Peds) | Up to 40 mg/kg | Every 8 hours |
| Renal impairment | Dose adjusted based on creatinine clearance (CrCl) |
- IV infusion over 15โ30 minutes
- IM use possible with appropriate diluent (e.g., 1% lidocaine, if approved)
โ ๏ธ Precautions:
- Adjust dose in renal insufficiency
- Monitor for neurological effects in high doses or renal impairment
- Use caution in patients with a history of ฮฒ-lactam allergy
โ Contraindications:
- Hypersensitivity to meropenem or other carbapenems/ฮฒ-lactam antibiotics
- Not recommended for neonates <3 months (insufficient safety data)
๐ฅ Common Side Effects:
- Diarrhea, nausea, vomiting
- Headache
- Skin rash or injection site reactions
- Seizures (rare, higher risk in renal dysfunction or CNS disease)
- Elevated liver enzymes