Here is the detailed information for:
💉 Enoxaparin Injection 40 mg/0.4 mL
✅ DESCRIPTION
Enoxaparin is a low molecular weight heparin (LMWH) used as an anticoagulant to prevent and treat blood clots. It works by inhibiting Factor Xa and thrombin (Factor IIa), thus preventing fibrin formation.
⚖️ COMPOSITION
- Each 0.4 mL prefilled syringe contains:
- Enoxaparin sodium 40 mg
- In sterile, preservative-free aqueous solution for subcutaneous injection
📌 INDICATIONS / USES
- Prophylaxis of deep vein thrombosis (DVT) in:
- Post-surgical patients
- Immobile medical patients
- Treatment of acute DVT or pulmonary embolism (PE)
- Acute coronary syndrome (ACS):
- Unstable angina
- NSTEMI
- Bridging anticoagulation during interruption of oral anticoagulants
- COVID-19–related thromboprophylaxis (as per protocol)
🌟 ADVANTAGES
- Predictable anticoagulant response (no frequent monitoring needed)
- Longer half-life than unfractionated heparin (UFH)
- Administered subcutaneously, no IV line required
- Suitable for home use in many cases
⚠️ PRECAUTIONS
- Renal impairment (reduce dose or avoid in severe cases)
- Bleeding risk – avoid in active bleeding, recent stroke, GI ulcers
- Monitor in elderly, underweight, or obese patients
- Avoid IM injections during therapy (risk of hematoma)
- Heparin-induced thrombocytopenia (HIT) – monitor platelets
❌ SIDE EFFECTS
- Bleeding (internal or external)
- Injection site reactions – pain, bruising
- Rare: thrombocytopenia, osteopenia (long-term use)
💊 DOSAGE & ADMINISTRATION
- Prophylaxis (general surgery or medical):
- 40 mg SC once daily
- Start 2 hours before surgery or upon hospitalization
- Renal impairment (CrCl <30 mL/min):
- 20 mg SC once daily
🕑 Onset: 3–5 hours
🕒 Duration: 12–24 hours
🚫 Do not administer IM or IV
📦 PACKING
- Pre-filled syringe: 40 mg in 0.4 mL (also available in 20 mg/0.2 mL, 60 mg/0.6 mL, etc.)
🧊 STORAGE
- Store below 25°C
- Do not freeze
- Use syringe immediately after opening
- Keep in original carton to protect from light