💊 Domperidone Oral Liquid 1 mg/mL – As Licensed
📄 Description:
Domperidone Oral Liquid 1 mg/mL is a dopamine (D2) receptor antagonist used primarily to treat nausea and vomiting, and to enhance gastric motility. The oral liquid form is especially suitable for children and patients who have difficulty swallowing tablets.
🧾 Prescription / Indications:
Prescribed for:
- Nausea and vomiting due to various causes
- Gastroesophageal reflux disease (GERD) in infants and children
- Delayed gastric emptying
- Functional dyspepsia
- Sometimes used (off-label) to promote lactation in postpartum women
Typical dosing:
- Infants & Children: 0.25–0.5 mg/kg per dose, 3 times daily before meals
- Adults: 10 mg (i.e., 10 mL) up to 3 times daily before meals
(Adjust dose per physician’s advice)
🔬 Nature:
- Class: Prokinetic and antiemetic agent
- Form: Oral solution
- Concentration: 1 mg/mL
- Route: Oral
🌟 Advantages:
- Easy to dose accurately in children
- Suitable for patients who cannot swallow pills
- Effective for both upper GI motility issues and emesis
- Less CNS penetration → fewer neurological side effects
📦 Packaging:
- Bottles commonly available in 30 mL, 60 mL, or 100 mL
- Supplied with measuring cup or oral syringe for accurate dosing
- Label includes concentration and dosage instructions
🧊 Storage:
- Store at room temperature, below 25°C
- Keep in original bottle, tightly closed
- Do not freeze
- Keep out of reach of children
⚠️ Precautions:
- Contraindicated in:
- Known or suspected QT prolongation
- Cardiac arrhythmias
- Severe liver disease
- Concomitant use of CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- Monitor for cardiac side effects, especially in infants or elderly
- Use lowest effective dose for shortest duration
Possible Side Effects:
- Abdominal cramps, dry mouth
- Headache, dizziness
- Rare: Heart rhythm abnormalities
👩⚕️ Patient Advice:
- Shake well before use
- Administer 15–30 minutes before meals
- Use measuring device provided (not a household spoon)
- Do not exceed prescribed dose or duration
- Inform the doctor if the child has:
- A history of heart disease
- Liver problems
- Symptoms like fainting or palpitations
- Do not give with antacids – may reduce absorption