:
💊 Spironolactone Tablet 25 mg – As Licensed
📄 Description:
Spironolactone 25 mg tablet is a potassium-sparing diuretic and aldosterone antagonist used to manage conditions like hypertension, edema, heart failure, liver cirrhosis, and hyperaldosteronism. It works by inhibiting the effects of aldosterone, promoting sodium and water excretion while conserving potassium.
🧾 Prescription / Use:
Indications:
- Edema associated with congestive heart failure, liver cirrhosis, or nephrotic syndrome
- Hypertension (adjunctive therapy)
- Primary hyperaldosteronism
- Hypokalemia (to prevent or treat)
- Hirsutism or polycystic ovary syndrome (PCOS) (off-label)
Dosage (Adults):
- Typically 25–100 mg daily, in single or divided doses
- Adjusted based on clinical response and serum potassium
Route: Oral
🔬 Nature:
- Pharmacologic class: Potassium-sparing diuretic / Aldosterone antagonist
- Mechanism: Competes with aldosterone at receptor sites in the distal renal tubules, increasing sodium and water excretion while retaining potassium
🌟 Advantages:
- Preserves serum potassium while reducing fluid overload
- Reduces mortality in heart failure (when used with ACE inhibitors)
- Treats ascites in liver cirrhosis
- Effective in resistant hypertension
📦 Common Packaging:
- Blister packs or strip packs
- Each strip contains 10 tablets of 25 mg
- Also available in 50 mg, 100 mg strengths
🧊 Storage:
- Store at room temperature (15°C to 25°C)
- Protect from moisture, light, and heat
- Keep out of reach of children
⚠️ Precautions:
Contraindications:
- Hyperkalemia
- Addison’s disease
- Severe renal impairment
- Hypersensitivity to spironolactone or components
Cautions:
- Monitor serum potassium and renal function regularly
- Risk of gynecomastia, menstrual irregularities, impotence, gastrointestinal upset
- Avoid potassium supplements, ACE inhibitors, or ARBs unless supervised
Side Effects:
- Hyperkalemia, nausea, drowsiness, leg cramps, breast tenderness, electrolyte imbalance
👩⚕️ Patient Advice:
- Take with food to reduce gastric upset
- Do not use salt substitutes (they often contain potassium)
- Report symptoms like muscle weakness, irregular heartbeat, or breast enlargement
- Regular blood tests may be needed to monitor potassium and kidney function
- Inform your doctor about other medications, especially ACE inhibitors or NSAIDs