Here is the complete non-branded profile for:
💧 Glucose Injection 50% (Dextrose 50%)
✅ DESCRIPTION
Glucose Injection 50% is a sterile, hypertonic intravenous solution containing 50 g of glucose per 100 mL of water for injection. It is primarily used for emergency correction of severe hypoglycemia and as a concentrated caloric source when fluid intake must be restricted.
🧪 FORMULATION
- Concentration: 50% w/v (50 g glucose in 100 mL)
- Form: Injectable solution
- Route: Intravenous (IV) only
- Typical volumes: 25 mL, 50 mL ampoules/vials
🌿 NATURE
- Highly hypertonic (osmolarity ~2520 mOsm/L)
- Non-pyrogenic, preservative-free
- Each mL provides 0.5 g of glucose
- High caloric density: ~1700 kcal/L
📌 USES
- Acute severe hypoglycemia, especially in unconscious or unresponsive patients
- Emergency management in diabetic coma
- Caloric supplementation when fluid restriction is necessary
- Occasionally used in hyperkalemia (with insulin)
🌟 ADVANTAGES
- Immediate reversal of hypoglycemia
- Requires smaller volume for high glucose delivery
- Compatible with insulin in specific protocols
- Useful in emergency and critical care settings
⚠️ PRECAUTIONS
- Must be administered via a secure IV line, preferably through a central vein (due to irritation risk)
- Avoid extravasation – can cause tissue necrosis
- Regularly monitor:
- Blood glucose
- Serum electrolytes
- Fluid balance
- Caution in patients with:
- Diabetes mellitus
- Renal insufficiency
- Heart failure
- Intracranial pressure elevation
❌ CONTRAINDICATIONS
- Hyperglycemia
- Diabetes (uncontrolled)
- Hypokalemia
- Fluid overload conditions
- Delirium tremens (with dehydration)
- Known glucose hypersensitivity
💢 SIDE EFFECTS
- Hyperglycemia
- Electrolyte imbalance (especially hyponatremia, hypokalemia)
- Phlebitis and vein irritation
- Local tissue damage from extravasation
- Fluid overload, pulmonary edema in high doses
📥 PACKING
- Available in ampoules or vials:
- 25 mL, 50 mL, sometimes 100 mL
- Single-dose only – discard unused portion
🧊 STORAGE
- Store at 15–25°C
- Protect from light
- Do not use if solution is discolored or contains particles
- Use immediately after opening