🔹 Insulin Premix 30:70 (Regular : NPH) Injection 40 IU/mL – As Licensed
📄 Description:
Insulin Premix 30:70 is a biphasic human insulin formulation that combines:
- 30% Regular (short-acting) insulin
- 70% NPH (intermediate-acting) insulin
This combination provides both immediate and prolonged blood glucose control. It is commonly used for patients with Type 1 and Type 2 diabetes mellitus.
💊 Prescription / Use:
- Indications:
- Type 1 Diabetes Mellitus
- Type 2 Diabetes Mellitus when oral agents fail
- Used in twice-daily dosing regimens
- Dosage Form:
- Injection: 40 IU/mL
- Supplied in 10 mL vials (400 IU total)
- Also available in 3 mL cartridges or prefilled pens
- Route:
- Subcutaneous (SC) injection only
- Common sites: abdomen, thigh, upper arm
- Frequency:
- Typically twice daily before meals (e.g., breakfast and dinner)
🔬 Nature:
- Biphasic insulin suspension
- Cloudy, white suspension (due to NPH component)
- Contains protamine and zinc for delayed absorption
- Onset: ~30 minutes
- Peak: 2–8 hours
- Duration: Up to 18 hours
🌟 Advantages:
- Dual action – covers both post-meal (prandial) and between-meal (basal) insulin needs
- Convenient fixed-dose combination
- Reduces total number of daily injections
- Helps control fasting and postprandial blood glucose
📦 Common Packaging:
- 10 mL vials at 40 IU/mL concentration
- 3 mL cartridges and prefilled pens (e.g., Insuman®, Mixtard®)
Label includes:
- Insulin type and ratio (30:70)
- Batch number, expiry date
- Storage conditions
- Instructions for use
🧊 Storage:
- Store in a refrigerator at 2°C–8°C
- Do not freeze
- Once opened, may be kept at room temperature (<25°C) for up to 28 days
- Keep away from direct sunlight and heat
- Before each use, gently roll or tilt to mix uniformly — do not shake vigorously
⚠️ Precautions:
- Do not mix with other insulin types
- Hypoglycemia risk if dose is not matched with food intake
- Ensure proper resuspension before injection
- Rotate injection sites to prevent lipodystrophy
- Monitor blood glucose levels regularly
👩⚕️ Patient Advice:
- Inject before meals, usually twice daily
- Eat soon after injecting to prevent hypoglycemia
- Learn the correct mixing technique (gently roll to resuspend)
- Watch for signs of low blood sugar: dizziness, sweating, hunger, tremors
- Keep glucose tablets or candy nearby
- Always use a new needle for each injection
- Discard opened vial/pen after 28 days
- Never freeze insulin or expose it to excess heat