Hepatitis B immunoglobulin As Licensed - Life Care Drugs and Medicines

✅ Name:

Hepatitis B Immunoglobulin (As Licensed)
(Common abbreviation: HBIG)

📄 Description:

Hepatitis B Immunoglobulin is a sterile solution of purified immunoglobulin (IgG) containing high titers of antibodies against the Hepatitis B surface antigen (anti-HBs). It provides passive immunity for prevention of Hepatitis B infection following exposure.

💊 Prescription/Use:

Indications:
- Post-exposure prophylaxis for:
  - Infants born to Hepatitis B surface antigen (HBsAg) positive mothers.
  - Sexual partners or household contacts of an acute Hepatitis B case.
  - Individuals with occupational or percutaneous exposure (e.g., needle stick injury).
- Non-responders to Hepatitis B vaccination after exposure.
Route of Administration:
- Intramuscular (IM) injection.
Dosage:
- Infants: 0.5 mL IM within 12 hours of birth.
- Adults: Usually 0.06 mL/kg body weight IM.
- Repeat doses may be required depending on exposure and vaccination status.

🔬 Nature:

Type: Passive immunization.
Source: Human plasma screened for viral infections.
Form: Liquid solution for intramuscular injection.
High titer anti-HBs antibodies.

🌟 Advantages:

Provides immediate protection against Hepatitis B virus (HBV).
Essential in high-risk exposure situations, especially where vaccination alone is insufficient.
Helps prevent vertical transmission from infected mothers to newborns.
Safe for use in infants, children, and adults, including pregnant women.

📦 Common Packaging:

Supplied in single-dose vials or prefilled syringes (commonly 0.5 mL or 1 mL).
Ready-to-use liquid formulation.
Pack includes product insert, vial/syringe, and sometimes alcohol swab.

🧊 Storage:

Store between 2°C to 8°C (Refrigerator).
Do not freeze.
Protect from light.
Do not use if the solution is discolored or contains particulate matter.

⚠️ Precautions:

Do not administer intravenously – only IM route.
Monitor for allergic reactions, especially in individuals with IgA deficiency.
May interfere with live vaccines (e.g., MMR) — observe proper timing for such vaccines.
Check the expiry date and inspect visually before use.

👩‍⚕️ Patient Advice:

Inform your healthcare provider of any allergies or bleeding disorders.
Mild pain or redness at the injection site is common.
Notify a doctor if symptoms of allergy or infection occur after injection.
This is not a substitute for the vaccine – Hepatitis B vaccination is still required for long-term protection.
Avoid receiving live vaccines for about 3 months after HBIG, unless advised otherwise.