Here is the complete and brand-free overview of Haloperidol Injection 5 mg/mL:
💉 Haloperidol Injection 5 mg/mL
✅ DESCRIPTION
Haloperidol Injection is a typical antipsychotic from the butyrophenone class used in acute psychiatric emergencies, agitation, or when oral administration is not feasible. It offers rapid symptom control, especially in patients with schizophrenia, delirium, or aggressive behavior.
🧪 FORMULATION
- Active Ingredient: Haloperidol 5 mg/mL
- Form: Clear, sterile injectable solution
- Route of Administration:
- Intramuscular (IM) — for rapid control
- Slow Intravenous (IV) — only under ECG monitoring
- Excipients May Include:
- Lactic acid (pH adjuster)
- Alcohol (as solvent)
- Water for Injection
🌿 NATURE
- Drug Class: Typical Antipsychotic / Neuroleptic
- Mechanism of Action:
Haloperidol blocks dopamine D2 receptors in the brain, especially in the mesolimbic system, reducing symptoms like hallucinations, delusions, and agitation.
💊 USES
- Acute Psychosis or Schizophrenic Agitation
- Acute Mania or Bipolar Agitation
- Delirium (including ICU settings)
- Severe Behavioral Disturbance
- Tics and Tourette Syndrome (in select cases)
- Preanesthetic sedation (occasionally used adjunctively)
🌟 ADVANTAGES
- Fast onset of action (within 20–30 mins IM)
- Ideal for non-cooperative or combative patients
- Useful when oral route is not possible
- Longer duration than some sedatives
- Helps prevent injury or escalation in psychiatric emergencies
⚠️ PRECAUTIONS
Common Side Effects:
- Drowsiness
- Muscle rigidity, tremors (extrapyramidal symptoms)
- Dizziness
- Injection site pain
Serious Side Effects:
- QT prolongation → cardiac arrhythmia (especially IV route)
- Neuroleptic Malignant Syndrome (NMS) – rare but life-threatening
- Tardive dyskinesia with repeated use
- Hypotension or respiratory depression
Contraindications:
- Parkinson’s disease
- Comatose or CNS-depressed states
- Known allergy to haloperidol
- Severe cardiac arrhythmias or prolonged QT
Special Caution:
- Elderly (risk of stroke, sudden death)
- Hepatic/renal impairment
- Concurrent use with other QT-prolonging drugs
- Use IV only with ECG monitoring
📏 DOSING GUIDANCE (as per clinician’s decision)
- IM: 2.5 – 10 mg, repeatable every 4–8 hours
- IV (Slow): 0.5 – 5 mg, usually diluted and under monitoring
- Max total dose and frequency depend on patient condition and weight
🧊 STORAGE
- Store at 15°C to 25°C (room temperature)
- Protect from light and excessive heat
- Do not freeze
- Use aseptic technique when withdrawing
- Discard unused portion as per protocol
- Keep out of reach of children