💊 Paracetamol Tablet 650 mg
📘 **Description:
Paracetamol (Acetaminophen)** is a widely used analgesic (pain reliever) and antipyretic (fever reducer). The 650 mg strength tablet is often used when a higher dose is needed for more persistent pain or fever, especially in adults.
🔬 Nature / Mechanism of Action:
Paracetamol works mainly in the central nervous system by:
- Inhibiting prostaglandin synthesis in the brain
- Acting on the hypothalamic heat-regulating center to reduce fever
Unlike NSAIDs, it has minimal anti-inflammatory activity and no significant gastrointestinal or bleeding risks.
🩺 Prescription / Uses:
| Indication | Use |
|---|---|
| Fever | High or persistent fever in adults |
| Headache & Migraine | Mild to moderate pain |
| Muscle aches | Flu-related or physical exertion |
| Joint pain / Osteoarthritis | Non-inflammatory pain |
| Toothache | Dental pain |
| Post-surgical pain | Mild to moderate severity |
| COVID-19 / Viral fever | Symptomatic relief of body pain, fever |
✅ Advantages:
- Safe and effective for most populations
- Well tolerated in stomach (non-acidic)
- Can be used in hypertension, heart disease, or gastric ulcer patients
- Suitable for pregnancy (under doctor’s advice)
- Preferred in COVID-19 for fever and myalgia
⚠️ Precautions:
- Use cautiously in:
- Liver disease
- Chronic alcohol users
- Those taking enzyme-inducing medications (e.g., rifampicin, phenytoin)
- Avoid combining with other paracetamol products to prevent overdose
📏 Typical Dosage:
| Group | Dose | Frequency |
|---|---|---|
| Adults | 650 mg orally | Every 6–8 hours (Max 4 g/day) |
| Children | Not typically used at this strength – use pediatric formulation |
Do not exceed 4,000 mg/day in adults.
📦 Storage:
- Store at room temperature (15–25°C)
- Keep away from heat, moisture, and direct sunlight
- Keep out of reach of children