💉 Diclofenac Injection 25 mg/mL
📘 **Description:
Diclofenac Sodium Injection 25 mg/mL** is a non-steroidal anti-inflammatory drug (NSAID) used for short-term management of moderate to severe pain, especially when oral administration is not suitable. It is commonly used post-operatively or for acute musculoskeletal conditions.
🔬 Formulation:
- Active Ingredient: Diclofenac Sodium
- Strength: 25 mg/mL
- Common Pack: 3 mL ampoule = 75 mg total dose
- Route of Administration: Intramuscular (IM), sometimes slow intravenous (IV) infusion (with dilution & caution)
🧪 Nature / Mechanism of Action:
- Drug Class: NSAID
- Mechanism:
- Inhibits cyclooxygenase (COX-1 and COX-2) enzymes
- ↓ Prostaglandin synthesis
- Result: ↓ Inflammation, pain, and fever
🩺 Uses / Indications:
| Condition | Purpose |
|---|---|
| Post-operative pain | Quick relief when oral meds not possible |
| Acute musculoskeletal pain | Back pain, sprains |
| Renal colic | Pain due to kidney stones |
| Dysmenorrhea (menstrual pain) | Short-term relief |
| Migraine (acute) | Emergency room use |
| Gout (acute attack) | Anti-inflammatory action |
✅ Advantages:
- Rapid onset of pain relief (within 10–30 minutes)
- Ideal for emergency settings
- Avoids first-pass metabolism
- Suitable when oral route is not feasible
⚠️ Precautions:
Use cautiously or avoid in:
- Gastrointestinal disorders (ulcers, bleeding)
- Cardiovascular disease (increased risk of stroke, MI)
- Renal or hepatic impairment
- Asthma (may trigger bronchospasm)
- Pregnancy (especially 3rd trimester)
- Children under 18 years (unless prescribed)
📦 Storage:
- Store at 15–25°C
- Protect from light and freezing
- Do not use discolored or precipitated solutions